Keynote Talk: Alexander Hoffmann [UdVQ8QZL203]

Title: A temporal signaling code to specify immune responses

Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. Our studies have revealed that immune sentinel cells have evolved a temporal code in grocery store the dynamics of stimulus-responsive transcription factors such as of NF?B. I will present recent experimental and computational studies that unraveled several aspects of this temporal code, e.g. 1) using an information theoretic approach to identify the codewords, termed signaling tchouameni codons, ed miliband 2) using a machine learning approach to characterize their reliability and points of confusion, 3) using dynamical systems modeling to characterize the molecular circuits that allow for their encoding, and 4) the development of digital twin macrophages that allow us to investigate the molecular basis and biological roles of heterogeneity.